abstract：BACKGROUND:Primary microcephaly is defined as reduced occipital-frontal circumference noticeable before 36 weeks of gestation. Large amount of insults might lead to microcephaly including infections, hypoxia and genetic mutations. More than 16 genes are described in autosomal recessive primary microcephaly. However, th...

journal_title：BMC neurology

authors： Picher-Martel V,Labrie Y,Rivest S,Lace B,Chrestian N

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with radiomics from conventional T1 contrast-enhanced (T1 CE) and fluid attenuated inversion recovery (FLAI...

journal_title：BMC neurology

authors： Zhao SS,Feng XL,Hu YC,Han Y,Tian Q,Sun YZ,Zhang J,Ge XW,Cheng SC,Li XL,Mao L,Shen SN,Yan LF,Cui GB,Wang W

更新日期：2020-02-07 00:00:00

abstract：BACKGROUND:While both hypercapnia and hypocapnia are harmful in patients with subarachnoid hemorrhage (SAH), it is unknown whether high-normal PaCO2 values are better than low-normal values. We hypothesized that high-normal PaCO2 values have more detrimental than beneficial effects on outcome. METHODS:Consecutive pati...

journal_title：BMC neurology

authors： Reiff T,Barthel O,Schönenberger S,Mundiyanapurath S

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Active Rehabilitation (AR) is a community peer-based concept for people with spinal cord injury (SCI) that is primarily delivered through brief residential training programmes. Despite a plethora of positive anecdotal evidence of AR programmes as life-changing experiences, the effects of AR-programmes have n...

journal_title：BMC neurology

authors： Divanoglou A,Tasiemski T,Jörgensen S

更新日期：2020-01-11 00:00:00

abstract：BACKGROUND:Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-rela...

journal_title：BMC neurology

authors： Amano E,Uchida K,Ishihara T,Otsu S,Machida A,Eishi Y

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Stroke and its risk factors epidemiological survey can help identify individuals at higher risk and therefore promote stroke prevention strategies. The aim of this study was to estimate the current prevalence of stroke and high risk stroke population, and evaluate stroke associated risk factors in southweste...

journal_title：BMC neurology

authors： Yi X,Luo H,Zhou J,Yu M,Chen X,Tan L,Wei W,Li J

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Chest pain as the primary manifestation of epilepsy is extremely rare and has only been reported once to date. CASE PRESENTATION:We herein describe a 47-year-old woman with recurrent chest pain for 3 years. The cause of her chest pain remained elusive despite extensive investigations including comprehensive...

journal_title：BMC neurology

authors： Khoo CS,Lee D,Park KM,In Lee B,Kim SE

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:A fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at admission in predicting PMD. METHODS:From January 2015 to September 2018, consecutive patients with P...

journal_title：BMC neurology

authors： Gong P,Liu Y,Huang T,Chen W,Jiang T,Gong Y,Lu M,Wang M,Zhang Y,Zhang X,Deng Q,Zhou J

更新日期：2019-12-29 00:00:00

abstract：BACKGROUND:Admission hyperglycemia (HG) has been associated with worse outcomes among acute stroke patients. A better understanding and awareness of the potentially adverse influence of hyperglycemia on the clinical outcome of acute stroke patients would help to provide guidance for acute stroke management and preventi...

journal_title：BMC neurology

authors： Zewde YZ,Mengesha AT,Gebreyes YF,Naess H

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:The narcolepsy severity scale (NSS) was developed to measure the severity and consequences of symptoms in patients with narcolepsy. The scale has been validated in France, though no other studies have further validated this instrument. The current study aimed to present psychometric properties and describe t...

journal_title：BMC neurology

authors： Ouyang H,Han F,Zheng Q,Zhang J

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:This study aims to investigate the clinical value of two kinds of vestibular-evoked myogenic potentials in patients with sudden sensorineural hearing loss (SSNHL). METHODS:A total of 82 patients were divided into two groups: vertigo group and non-vertigo group. All patients underwent examinations for pure t...

journal_title：BMC neurology

authors： Wang Y,Gu ST,Bao XL,Guo JL

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:The X-linked form of Charcot-Marie-Tooth disease type 1 (CMTX1) is an inherited peripheral neuropathy that arises in patients with mutations in the gap-junction beta-1 gene (GJB1). CASE PRESENTATION:Three young male patients from Southern China with pes cavus experienced multiple episodes of transient centr...

journal_title：BMC neurology

authors： Liang Y,Liu J,Cheng D,Wu Y,Mo L,Huang W

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Spinal cord infarction (SCI) is rarely caused by vertebral artery dissection (VAD), which is an important cause of posterior circulation stroke in young and middle-aged patients. We report the case of a middle-aged patient without obvious risk factors for atherosclerosis who had SCI from right VAD. CASE PRE...

journal_title：BMC neurology

authors： Meng YY,Dou L,Wang CM,Kong DZ,Wei Y,Wu LS,Yang Y,Zhou HW

更新日期：2019-12-12 00:00:00

abstract：BACKGROUND:Patients with acute stroke are particularly vulnerable to delirium episodes. Although delirium detection is important, no evidence-based recommendations have been established to date on how these patients should be routinely screened for delirium or which tool should be used for this purpose in this populati...

journal_title：BMC neurology

authors： Mansutti I,Saiani L,Palese A

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Progressive Supranuclear Palsy (PSP) is the most frequent form of atypical Parkinsonism. Although there is preliminary evidence for the benefits of gait rehabilitation, balance training and oculomotor exercises in PSP, the quality of reporting of exercise therapies appears mixed. The current investigation ai...

journal_title：BMC neurology

authors： Slade SC,Underwood M,McGinley JL,Morris ME

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:The benefit of intravenous thrombolysis (IVT) for acute ischemic stroke is time dependent. Despite great effort, the median door-to-needle time (DNT) was 60 min at the United States stroke centers. We investigated the effect of a simple quality improvement initiative on DNT for IVT. METHODS:This is a single...

journal_title：BMC neurology

authors： Tran D,Zhu Z,Shafie M,Abcede H,Stradling D,Yu W

更新日期：2019-11-26 00:00:00

abstract：BACKGROUND:In this paper, seizure types, and epilepsy syndromes are elucidated as per ILAE (2010) classification. A brief outline of the antiepileptic drug regimens used and the outcome of seizure control in a two -year period is presented. The applicability of the ILAE classification in resource limited countries has ...

journal_title：BMC neurology

authors： Mohamed IN,Elseed MA,Mohamed S,Alsir A,Hamid EK,Omer IM,Elsadig SM,Gerais YM,Osman AH,Bakhiet AM,Hamed AA

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause involving the brain and accompanied by prominent eosinophilia. Intracardiac thrombosis is a major cardiac complication of EGPA that may cause thromboembolism. CASE PRESENTATION:A 53-year-old man presenting wi...

journal_title：BMC neurology

authors： Hira K,Shimura H,Kamata R,Takanashi M,Hashizume A,Takahashi K,Sugiyama M,Izumi H,Hattori N,Urabe T

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Spastic paraplegia, optic atrophy and neuropathy (Spoan syndrome) is an autosomal recessive disease with approximately 70 cases recorded in Brazil and Egypt. METHODS:This is a prospective longitudinal study performed with 47 patients affected with Spoan syndrome of seven communities of Rio Grande do Norte (...

journal_title：BMC neurology

authors： Galvão CRC,Cavalcante PMA,Olinda R,Graciani Z,Zatz M,Kok F,Santos S,Lancman S

更新日期：2019-10-27 00:00:00

abstract：:Following publication of the original article [1], the authors reported an error in Table 2 wherein the item numbering in the first column is wrong. ...

journal_title：BMC neurology

authors： da Silva ESM,Santos GL,Catai AM,Borstad A,Furtado NPD,Aniceto IAV,Russo TL

更新日期：2019-09-13 00:00:00

abstract：BACKGROUND:Facioscapulohumeral muscular dystrophy (FSHD) is a dominantly-inherited progressive muscular dystrophy caused by de-repression of the DUX4 gene, which causes disease by a toxic-gain-of-function. As molecularly targeted drugs move from preclinical testing into human trials, it is essential that we validate cl...

journal_title：BMC neurology

authors： LoRusso S,Johnson NE,McDermott MP,Eichinger K,Butterfield RJ,Carraro E,Higgs K,Lewis L,Mul K,Sacconi S,Sansone VA,Shieh P,van Engelen B,Wagner K,Wang L,Statland JM,Tawil R,ReSolve Investigators and the FSHD CTRN18.

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:Sciatica is a condition that is characterised by radicular pain in the leg and primarily caused by a herniated lumbar intervertebral disk. In addition to leg pain, patients can experience back pain, leg numbness and leg weakness resulting in decreased productivity and social activity. The majority of sciatic...

journal_title：BMC neurology

authors： Verheijen E,Munts AG,van Haagen O,de Vries D,Dekkers O,van den Hout W,Vleggeert-Lankamp C

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO...

journal_title：BMC neurology

authors： Kim HJ,Cho H,Park S,Jang H,Ryu YH,Choi JY,Moon SH,Oh SJ,Oh M,Na DL,Lyoo CH,Kim EJ,Seeley WW,Kim JS,Choi KC,Seo SW

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Interleukin 36 (IL-36) cytokines belong to the IL-1 family and play an important role in some autoimmune diseases. However, the relationship between IL-36 and neuromyelitis optica spectrum disorders (NMOSD) remains unclear. METHODS:We determined serum IL-36α, IL-36β and IL-36γ levels and assessed correlatio...

journal_title：BMC neurology

authors： Yang CS,Zhang QX,Deng Y,Zhou BJ,Zhang LJ,Li LM,Qi Y,Wang J,Yang L,Shi FD

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a common CDUS artifact known as acoustic shadow (AS). Our objective was to assess the change in relia...

journal_title：BMC neurology

authors： Seyman EE,Bornstein N,Auriel E,Cohen O,Nissel T,Hallevi H

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:The coexistence of distinct neurodegenerative diseases in single cases has recently attracted greater attention. The phenotypic co-occurrence of progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) has been documented in several cases. That said, the clinicopathological comorbidity of...

journal_title：BMC neurology

authors： Fujita K,Matsubara T,Miyamoto R,Sumikura H,Takeuchi T,Maruyama Saladini K,Kawarai T,Nodera H,Udaka F,Kume K,Morino H,Kawakami H,Hasegawa M,Kaji R,Murayama S,Izumi Y

更新日期：2019-07-18 00:00:00

abstract：BACKGROUND:Intravenous thrombolysis has been recently introduced in Nepal for the management of acute ischemic stroke. Pre-hospital delay is one of the main reasons that hinder thrombolytic therapy. The objective of this study was to evaluate the status of prehospital delay and thrombolysis in Nepal. METHODS:Data were...

journal_title：BMC neurology

authors： Nepal G,Yadav JK,Basnet B,Shrestha TM,Kharel G,Ojha R

更新日期：2019-07-09 00:00:00

abstract：BACKGROUND:Almost 40% of stroke patients have a poor outcome at 3 months after the index event. Predictors for stroke outcome in the early acute phase may help to tailor stroke treatment. Infection and inflammation are considered to influence stroke outcome. METHODS:In a prospective multicenter study in Germany and Sp...

journal_title：BMC neurology

authors： Mengel A,Ulm L,Hotter B,Harms H,Piper SK,Grittner U,Montaner J,Meisel C,Meisel A,Hoffmann S

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:The use of vestibular rehabilitation principles in the management of gaze and postural stability impairments in people with multiple sclerosis (PwMS) has shown promise in pilot work completed in our lab and in a recently published randomized clinical trial (RCT). However, further work is needed to fully quan...

journal_title：BMC neurology

authors： Loyd BJ,Fangman A,Peterson DS,Gappmaier E,Schubert MC,Thackery A,Dibble L

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Internal jugular vein stenosis (IJVS), characterized by a series of clinical manifestations, such as head and neck symptoms, visual and ear symptoms, as well as sleep disorder, has been receiving attention in recent years. However, its' etiologies are not fully understood. CASE PRESENTATION:We report a case...

journal_title：BMC neurology

authors： Li M,Sun Y,Chan CC,Fan C,Ji X,Meng R

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between Carbamazepine-resistant (CBZ-resistant) epilepsy and EPHX1 methylation in a northern Han Chinese po...

journal_title：BMC neurology

authors： Lv Y,Zheng X,Shi M,Wang Z,Cui L

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Type 2 Diabetes in Mexico has a high prevalence, 16-87% of patients may experience peripheral neuropathy. Early detection can prevent or halt its progression. The performance of Sudoscan in detecting neuropathy was compared to the Michigan Neuropathy Screening Instrument (MNSI). The aim was to identificate s...

journal_title：BMC neurology

authors： Carbajal-Ramírez A,Hernández-Domínguez JA,Molina-Ayala MA,Rojas-Uribe MM,Chávez-Negrete A

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Lumbo-sacral radiculopathy (LSR) is a common musculoskeletal disorder for which patients seek medical care and referrals for advanced imaging. However, accurate diagnosis remains challenging. Neuropathic pain screening questionnaires, clinical neurological examination and magnetic resonance imaging (MRI) are...

journal_title：BMC neurology

authors： Tawa N,Diener I,Louw Q,Rhoda A

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting as refractory epilepsy is rare. Here we report a young female GBC patient who presented with an atyp...

journal_title：BMC neurology

authors： Pandey S,Garg RK,Malhotra HS,Uniyal R,Kumar N

更新日期：2019-05-10 00:00:00

abstract：BACKGROUND:Sturge-Weber syndrome (SWS) is a rare and sporadic congenital neurocutaneous disorder, that is characterized by facial venous capillary malformation (port-wine birthmark), leptomeningeal venous malformation (angiomatosis), glaucoma, and neurologic problems. SWS can comorbid with other disorders in some patie...

journal_title：BMC neurology

authors： Deng L,Wang D,Ruan N,Fu P

更新日期：2019-05-03 00:00:00

abstract：BACKGROUND:Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer's disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise that skin vascular response to iontophoresis of acetylcholine, which is partly determined by the le...

journal_title：BMC neurology

authors： Connelly PJ,Adams F,Tayar ZI,Khan F

更新日期：2019-05-03 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT) is a severe neurodevelopmental disorder mainly affecting females. One of the main clinical manifestations is hand stereotypies, which is presumed to based on dysfunction rather than on structural impairment. Reflex interictal discharge precipitated by tapping-lips in electroencephalogram ...

journal_title：BMC neurology

authors： Luo X,Li C,Wang X,Yu X,Jiang J

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Embolectomy is the standard of care in acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). Aim of this study was to compare two techniques: A Direct Aspiration First Pass Technique (ADAPT) and Stent-retriever Assisted Vacuum-locked Extraction (SAVE) stratified by the occluded vessel. METHODS...

journal_title：BMC neurology

authors： Brehm A,Maus V,Tsogkas I,Colla R,Hesse AC,Gera RG,Psychogios MN

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Primary familial brain calcification is a rare autosomal dominant or recessive neurodegenerative disease, characterized by bilateral brain calcifications in different areas of the brain. It is a clinically heterogeneous disease and patients are reported to exhibit a wide spectrum of neurological and psychiat...

journal_title：BMC neurology

authors： Mathorne SW,Sørensen K,Fagerberg C,Bode M,Hertz JM

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:Dopaminergic neuronal loss begins years before motor symptoms appear in Parkinson disease (PD). Thus, reliable biomarkers for early diagnosis and prognosis of PD are an essential pre-requisite to develop disease modifying therapies. Inflammation-derived oxidative stress is postulated to contribute to nigrost...

journal_title：BMC neurology

authors： Rathnayake D,Chang T,Udagama P

更新日期：2019-04-06 00:00:00